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Effects of spaceflight on rat pituitary cell functionThe secretory capacity of growth hormone (GH) and prolactin (PRL) cells prepared from rats flown in space on the 12.5 day mission of Cosmos 1887 and the 14 day mission of Cosmos 2044 was evaluated in several post-flight tests on earth. The results showed statistically significant and repeatable decrements in hormone release, especially when biological assays (rather than immunological assays) were used in the tests. Significant and repeatable intracellular changes in GH cells from the flight animals were also found; most important were increases in the GH-specific cytoplasmic staining intensities and cytoplasmic areas occupied by hormone. Tail suspension of rats for 14 days, an established model for mimicking musculo-skeletal changes seen in spaceflown rats, results in some changes in GH and PRL cell function that were similar to those from spaceflown animals. Our results add to a growing body of data that described deconditioning of physiological systems in spaceflight and provide insights into the time frame that might be required for readaptation of the GH/PRL cell system upon return to earth.
Document ID
19920068869
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hymer, W. C.
(NASA Ames Research Center Moffett Field, CA, United States)
Grindeland, R.
(NASA Ames Research Center Moffett Field, CA, United States)
Krasnov, I.
(NASA Ames Research Center Moffett Field, CA, United States)
Viktorov, I.
(NASA Ames Research Center Moffett Field, CA, United States)
Motter, K.
(NASA Ames Research Center Moffett Field, CA, United States)
Mukherjee, P.
(NASA Ames Research Center Moffett Field, CA, United States)
Shellenberger, K.
(NASA Ames Research Center Moffett Field, CA, United States)
Vasques, M.
(Pennsylvania State University, University Park; NASA, Ames Research Center Moffett Field, CA; Brain Research Institute and Institute of Biomedical Problems, Moscow, Russia)
Date Acquired
August 15, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of Applied Physiology, Supplement
Volume: 73
Issue: 2 Au
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
92A51493
Funding Number(s)
CONTRACT_GRANT: NAG2-481
CONTRACT_GRANT: NCC2-370
CONTRACT_GRANT: NAG2-598
CONTRACT_GRANT: NAGW-1196
Distribution Limits
Public
Copyright
Other

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