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Circulating parathyroid hormone and calcitonin in rats after spaceflightParathyroid hormone and calcithonin, two major calcium-regulating hormones, were measured in the plasma of five experimental groups of rats to evaluate postflight calcium homeostasis after the 14-day Cosmos 2044 flight. Parathyroid hormone values were slightly higher in the flight animals (F) than in the appropriate cage and diet controls (S) (44 +/- 21 vs 21 +/- 4 pg/ml, P less than 0.05), but they were the same as in the vivarium controls (V), which had different housing and feeding schedules. The difference in F and V (22 +/- 11 vs 49 +/- 16 pg/ml, P less than 0.05) was most likely due to failure of circulating calcitonin in F to show the normal age-dependent increase which was demonstrated in age-matched controls in a separate experiment. Basal values for parathyroid hormone and calcitonin were unchanged after 2 wk of hindlimb suspension, a flight simulation model, in age-matched and younger rats. From a time course experiment serum calcium was higher and parathyroid hormone lower after 4 wk than in ambulatory controls. Postflight circulating levels of parathyroid hormone appear to reflect disturbances in calcium homeostasis from impaired renal function of undetermined cause, whereas levels of calcitonin reflect depression of a normal growth process.
Document ID
19920068872
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Arnaud, Sara B.
(NASA Ames Research Center Moffett Field, CA, United States)
Fung, Paul
(NASA Ames Research Center Moffett Field, CA, United States)
Popova, Irina A.
(NASA Ames Research Center Moffett Field, CA, United States)
Morey-Holton, Emily R.
(NASA Ames Research Center Moffett Field, CA, United States)
Grindeland, Richard E.
(NASA Ames Research Center Moffett Field, CA; Institute of Biomedical Problems, Moscow, Russia)
Date Acquired
August 15, 2013
Publication Date
August 1, 1992
Publication Information
Publication: Journal of Applied Physiology, Supplement
Volume: 73
Issue: 2 Au
ISSN: 8750-7587
Subject Category
Life Sciences (General)
Accession Number
92A51496
Funding Number(s)
PROJECT: RTOP 199-14-12-08
PROJECT: RTOP 199-26-12-02
PROJECT: RTOP 199-26-12-09
PROJECT: RTOP 199-40-42-01
Distribution Limits
Public
Copyright
Other

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