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Monolithic Continuous-Flow BioreactorsMonolithic ceramic matrices containing many small flow passages useful as continuous-flow bioreactors. Ceramic matrix containing passages made by extruding and firing suitable ceramic. Pores in matrix provide attachment medium for film of cells and allow free movement of solution. Material one not toxic to micro-organisms grown in reactor. In reactor, liquid nutrients flow over, and liquid reaction products flow from, cell culture immobilized in one set of channels while oxygen flows to, and gaseous reaction products flow from, culture in adjacent set of passages. Cells live on inner surfaces containing flowing nutrient and in pores of walls of passages. Ready access to nutrients and oxygen in channels. They generate continuous high yield characteristic of immobilized cells, without large expenditure of energy otherwise incurred if necessary to pump nutrient solution through dense biomass as in bioreactors of other types.
Document ID
19930000055
Acquisition Source
Legacy CDMS
Document Type
Other - NASA Tech Brief
Authors
Stephanopoulos, Gregory
(Caltech)
Kornfield, Julia A.
(Caltech)
Voecks, Gerald A.
(Caltech)
Date Acquired
August 16, 2013
Publication Date
January 1, 1993
Publication Information
Publication: NASA Tech Briefs
Volume: 17
Issue: 1
ISSN: 0145-319X
Subject Category
Life Sciences
Report/Patent Number
NPO-18542
Accession Number
93B10055
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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