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Role of atrial natriuretic peptide in systemic responses to acute isotonic volume expansionA hypothesis is proposed that a temporal relationship exists between increases in cardiac filling pressure and plasma artrial natriuretic peptide (ANP) concentration and also between ANP elevation and vasodilation, fluid movement from plasma to interstitium, and increased urine volume (UV). To test the hypothesis, 30 ml/kg isotonic saline were infused in supine male subjects over 24 min and responses were monitored for 3 h postinfusion. Results show that at end infusion, mean arterial pressure (RAP), heart rate and plasma volume exhibited peak increases of 146, 23, and 27 percent, respectively. Mean plasma ANP and UV peaked (45 and 390 percent, respectively) at 30 min postinfusion. Most cardiovascular variables had returned toward control levels by 1 h postinfusion, and net reabsorption of extravascular fluid ensued. It is concluded that since ANP was not significantly increased until 30 min postinfusion, factors other than ANP initiate responses to intravascular fluid loading. These factors include increased vascular pressures, baroreceptor-mediated vasolidation, and hemodilution of plasma proteins. ANP is suggested to mediate, in part, the renal response to saline infusion.
Document ID
19930030971
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Watenpaugh, Donald E.
(NASA Ames Research Center Moffett Field, CA, United States)
Yancy, Clyde W.
(NASA Ames Research Center Moffett Field, CA, United States)
Buckey, Jay C.
(NASA Ames Research Center Moffett Field, CA, United States)
Lane, Lynda D.
(NASA Ames Research Center Moffett Field, CA, United States)
Hargens, Alan R.
(NASA Ames Research Center Moffett Field, CA, United States)
Blomqvist, C. G.
(Texas Univ., Dallas; NASA, Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 16, 2013
Publication Date
October 1, 1992
Publication Information
Publication: Journal of Applied Physiology
Volume: 73
Issue: 4
ISSN: 8750-7587
Subject Category
Aerospace Medicine
Accession Number
93A14968
Funding Number(s)
CONTRACT_GRANT: NGT-50206
CONTRACT_GRANT: NAS9-16044
CONTRACT_GRANT: NAG9-267
Distribution Limits
Public
Copyright
Other

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