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Protein crystallization aboard the Space Shuttle and the Mir space stationTwo different protein crystallizations, namely ,the free Fab fragment of the Je142 monoclonal antibody and the complex of Fab fragment/HPr with antigen, were performed aboard the Discovery Space Shuttle flights and the Mir space station, respectively. Medium sized crystals of the Je142 Fab fragment were obtained. The Je142 Fab fragment/Hpr complex produced two medium-sized crystals after two months aboard the Mir space station. Microgravity was found to eliminate the tendency of these crystals to form clusters.
Document ID
19930040813
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Delbaere, Louis T. J.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Vandonselaar, Margaret
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Prasad, Lata
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Quail, J. W.
(Saskatchewan Univ. Saskatoon, Canada)
Birnbaum, George I.
(National Research Council of Canada Inst. of Biological Sciences, Ottawa, United States)
Delucas, Lawrence J.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Moore, Karen
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Bugg, Charles E.
(Alabama Univ. Birmingham, United States)
Date Acquired
August 16, 2013
Publication Date
January 1, 1993
Subject Category
Materials Processing
Report/Patent Number
AIAA PAPER 93-0718
Meeting Information
Meeting: AIAA, Aerospace Sciences Meeting and Exhibit
Location: Reno, NV
Country: United States
Start Date: January 11, 1993
End Date: January 14, 1993
Sponsors: AIAA
Accession Number
93A24810
Funding Number(s)
CONTRACT_GRANT: NAGW-813
CONTRACT_GRANT: NAS8-36611
Distribution Limits
Public
Copyright
Other

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