NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Dopamine release in rat striatum - Physiological coupling to tyrosine supplyIntracerebral microdialysis was used to monitor dopamine release in rat striatal extracellular fluid following the intraperitoneal administration of dopamine's precursor amino acid, L-tyrosine. Dopamine concentrations in dialysates increased transiently after tyrosine (50-100 mg/kg) administration. Pretreatment with haloperidol or the partial lesioning of nigrostriatal neurons enhanced the effect of tyrosine on dopamine release, and haloperidol also prolonged this effect. These data suggest that nigrostriatal dopaminergic neurons are responsive to changes in precursor availability under basal conditions, but that receptor-mediated feedback mechanisms limit the magnitude and duration of this effect.
Document ID
19930043053
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
During, Matthew J.
(NASA Headquarters Washington, DC United States)
Acworth, Ian N.
(NASA Headquarters Washington, DC United States)
Wurtman, Richard J.
(MIT Cambridge, MA, United States)
Date Acquired
August 16, 2013
Publication Date
January 1, 1989
Publication Information
Publication: Journal of Neurochemistry
Volume: 52
Issue: 5
ISSN: 0022-3042
Subject Category
Life Sciences (General)
Accession Number
93A27050
Distribution Limits
Public
Copyright
Other

Available Downloads

There are no available downloads for this record.
No Preview Available