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Rett syndrome - Stimulation of endogenous biogenic aminesTransient hypercapnic hyperoxemia was induced in two Rett syndrome children by the administration of a gaseous mixture of 80 percent O2 and 20 percent CO2. Time course studies of neurotransmitters and their metabolites showed an immediate and marked increase in central biogenic amine turnover following inhalation of the gas mixture. The increased turnover of biogenic amines was associated with improved clinical changes. This suggests a coupled relationship and provides further support for an etiological role of neurotransmitter dysfunction in Rett syndrome. In a complementary study, elevation of pulmonary CO2 by application of a simple rebreathing device resulted in improvement of abnormal blood gases and elimination of the Cheyne-Stokes-like respiratory pattern of the Rett syndrome. Near normalization of the EEG occurred when a normal respiratory pattern was imposed by means of a respirator. Taken together, these results lead to the preliminary conclusion that cerebral hypoxemia secondary to abnormal respiratory function may contribute to diminished production of biogenic amines in Rett syndrome.
Document ID
19930044700
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Pelligra, R.
(NASA Ames Research Center Moffett Field, CA, United States)
Norton, R. D.
(NASA Ames Research Center Moffett Field, CA, United States)
Wilkinson, R.
(NASA Ames Research Center Moffett Field, CA, United States)
Leon, H. A.
(NASA Ames Research Center Moffett Field, CA, United States)
Matson, W. R.
(NASA Ames Research Center Moffett Field, CA, United States)
Date Acquired
August 16, 2013
Publication Date
June 1, 1992
Publication Information
Publication: Neuropediatrics
Volume: 23
Issue: 3
ISSN: 0174-304X
Subject Category
Aerospace Medicine
Accession Number
93A28697
Distribution Limits
Public
Copyright
Other

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