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In vivo testing confirms a blunting of the human cell-mediated immune mechanism during space flightThe cell-mediated immune (CMI) mechanism was evaluated in 10 space shuttle astronauts by measuring their delayed-type hypersensitivity response to seven common recall antigens. The Multitest CMI test system was used to administer antigens of tetanus, diphtheria, Streptococcus, Proteus, old tuberculin, Candida, and Trichophyton to the forearm 46 h before nominal mission termination; readings were conducted 2 h after landing. The mean number of reactions was reduced from 4.5 preflight to 3.0 inflight, and the mean reaction score was reduced from 21.4 to 13.7 mm inflight. The data presented suggest that the CMI system is still being degraded by space flight conditions on day 4 and that between day 5 and day 10, the depression maximizes and the system begins to adjust to the new conditions. The relation of these in vivo findings to previously reported in vitro results is discussed.
Document ID
19930044735
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Taylor, G. R.
(NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Janney, R. P.
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 16, 2013
Publication Date
February 1, 1992
Publication Information
Publication: Journal of Leukocyte Biology
Volume: 51
Issue: 2
ISSN: 0741-5400
Subject Category
Aerospace Medicine
Accession Number
93A28732
Distribution Limits
Public
Copyright
Other

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