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Alanine increases blood pressure during hypotensionThe effect of L-alanine administration on blood pressure (BP) during haemorrhagic shock was investigated using anesthetized rats whose left carotid arteries were cannulated for BP measurement, blood removal, and drug administration. It was found that L-alanine, in doses of 10, 25, 50, 100, and 200 mg/kg, increased the systolic BP of hypotensive rats by 38 to 80 percent (while 100 mg/kg pyruvate increased BP by only 9.4 mmhg, not significantly different from saline). The results suggest that L-alanine might influence cardiovascular function.
Document ID
19930049030
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Conlay, L. A.
(MIT Cambridge; Massachusetts General Hospital; Harvard Medical School, Boston, United States)
Maher, T. J.
(MIT Cambridge; Massachusetts College of Pharmacy and Allied Health Sciences, Boston, United States)
Wurtman, R. J.
(MIT Cambridge, MA, United States)
Date Acquired
August 16, 2013
Publication Date
January 1, 1990
Publication Information
Publication: Pharmacology & Toxicology
ISSN: 0901-9928
Subject Category
Life Sciences (General)
Accession Number
93A33027
Funding Number(s)
CONTRACT_GRANT: NIH-R23-3026
Distribution Limits
Public
Copyright
Other

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