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Effects of their nutrient precursors on the synthesis and release of serotonin, the catecholamines, and acetylcholine - Implications for behavioral disordersAuthentic foods affect brain serotonin synthesis by modifying brain tryptophan levels, carbohydrates increasing and proteins decreasing these levels. The carbohydrate-induced rise in brain serotonin tends to diminish the likelihood that one carbohydrate-rich, protein-poor meal or snack will be followed by another. This mechanism is apparently disturbed in carbohydrate-craving obesity, which may explain why this syndrome responds well to d-fenfluramine, a serotoninergic drug. Pure nutrients like tyrosine or choline can also affect the rates at which their neurotransmitter products, the catecholamines and acetylcholine, are synthesized in and released from nerve terminals, suggesting that these compounds may find uses as drugs.
Document ID
19930049036
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Wurtman, Richard J.
(MIT Cambridge, MA, United States)
Date Acquired
August 16, 2013
Publication Date
January 1, 1988
Publication Information
Publication: Clinical Neuropharmacology
Volume: 11
ISSN: 0362-5664
Subject Category
Life Sciences (General)
Accession Number
93A33033
Distribution Limits
Public
Copyright
Other

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