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Norepinephrine content in discrete brain areas and neurohypophysial vasopressin in rats after a 9-d spaceflight (SLS-1)The norepinephrine (NE) content in discrete brain areas and the vasopressin content in the neurohypophysial system were assessed in rats after a 9-d spaceflight and after a recovery period. The NE content in the locus coeruleus decreased significantly in spaceflight rats, but showed no difference between control and flight animals after a 9-d recovery. These findings were probably due to an acute stress undergone during landing. The NE content was unchanged in the A2 and A5 cell groups. In rats flown aboard SLS-1, the vasopressin content was increased in the posterior pituitary, and was significantly decreased in the hypothalamus. We conclude that the NE depletion in the locus coeruleus and the alteration in vasopressin release were consistent with an acute stress, likely occurring during and/or after landing. These changes tend to mask the actual neuroendocrine modifications caused by microgravity.
Document ID
19930057170
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Fareh, Jeannette
(NASA Ames Research Center Moffett Field, CA, United States)
Cottet-Emard, Jean-Marie
(NASA Ames Research Center Moffett Field, CA, United States)
Pequignot, Jean-Marc
(Lyon I, Univ. France)
Jahns, Gary
(NASA Ames Research Center Moffett Field, CA, United States)
Meylor, John
(Lockheed Engineering & Sciences Co.; NASA, Ames Research Center Moffett Field, CA, United States)
Viso, Michel
(NASA Ames Research Center Moffett Field, CA, United States)
Vassaux, Didier
(CNES Paris, France)
Gauquelin, Guillemette
(NASA Ames Research Center Moffett Field, CA, United States)
Gharib, Claude
(Lyon I, Univ. France)
Date Acquired
August 16, 2013
Publication Date
June 1, 1993
Publication Information
Publication: Aviation, Space, and Environmental Medicine
Volume: 64
Issue: 6
ISSN: 0095-6562
Subject Category
Life Sciences (General)
Accession Number
93A41167
Distribution Limits
Public
Copyright
Other

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