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Neuritogenesis: A model for space radiation effects on the central nervous systemPivotal to the astronauts' functional integrity and survival during long space flights are the strategies to deal with space radiations. The majority of the cellular studies in this area emphasize simple endpoints such as growth related events which, although useful to understand the nature of primary cell injury, have poor predictive value for extrapolation to more complex tissues such as the central nervous system (CNS). In order to assess the radiation damage on neural cell populations, we developed an in vitro model in which neuronal differentiation, neurite extension, and synaptogenesis occur under controlled conditions. The model exploits chick embryo neural explants to study the effects of radiations on neuritogenesis. In addition, neurobiological problems associated with long-term space flights are discussed.
Document ID
19940039073
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Vazquez, M. E.
(Columbia Univ. New York, NY, US, United States)
Broglio, T. M.
(Columbia Univ. New York, NY, US, United States)
Worgul, B. V.
(Columbia Univ. New York, NY, US, United States)
Benton, E. V.
(Univ. of San Francisco, San Francisco, CA US, United States)
Date Acquired
August 16, 2013
Publication Date
October 1, 1994
Publication Information
Publication: Life Sciences and Space Research 25 (2) Radiation Biology: Topical Meeting of the COSPAR Interdisciplinary Scientific Commission F of the COSPAR 29th Plenary Meeting, Washington, DC, Aug. 28-Sep. 5, 1
Volume: 14
Issue: 10
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
94A62522
Funding Number(s)
CONTRACT_GRANT: DOE-DE-FG02-90ER61009
CONTRACT_GRANT: NAG9-529
CONTRACT_GRANT: NAG9-235
Distribution Limits
Public
Copyright
Other

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