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Fluence-based relative biological effectiveness for charged particle carcinogenesis in mouse Harderian glandNeoplasia in the rodent Harderian gland has been used to determine the carcinogenic potential of irradiation by HZE particles. Ions from protons to lanthanum at energies up to 670 MeV/a have been used to irradiate mice, and prevalence of Harderian gland tumors has been measured 16 months after irradiation. The Relative Biological Effectiveness (RBE) for tumor induction has been expressed as the RBE(sub max), which is the ratio of the initial slopes of the dose vs prevalence curve. The RBE(sub max) has been found to be approximately 30 for ions with Linear Energy Transfer (LET) values in excess of 100 keV/micrometer. Analysis on the basis of fluence as a substitute for dose has shown that on a per particle basis all of the ions with LET values in excess of 100 keV/micrometer have equal effectiveness. An analysis of the probabilities of ion traversals of the nucleus has shown that for these high stopping powers that a single hit is effective in producing neoplastic transformation.
Document ID
19940039084
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Alpen, E. L.
(Univ. of California, Berkeley, CA U.S.A., United States)
Power-Risius, P.
(Univ. of California, Berkeley, CA U.S.A., United States)
Curtis, S. B.
(Univ. of California, Berkeley, CA U.S.A., United States)
Deguzman, R.
(Univ. of California, Berkeley, CA U.S.A., United States)
Fry, R. J. M.
(Oak Ridge National Lab. Oak Ridge, TN, U.S.A., United States)
Date Acquired
August 16, 2013
Publication Date
October 1, 1994
Publication Information
Publication: Life Sciences and Space Research 25 (2) Radiation Biology: Topical Meeting of the COSPAR Interdisciplinary Scientific Commission F of the COSPAR 29th Plenary Meeting, Washington, DC, Aug. 28-Sep. 5, 1
Volume: 14
Issue: 10
ISSN: 0273-1177
Subject Category
Life Sciences (General)
Accession Number
94A62533
Funding Number(s)
CONTRACT_GRANT: T1931M
CONTRACT_GRANT: DE-AC05-85OR21400
CONTRACT_GRANT: DE-AC03-76SF00098
Distribution Limits
Public
Copyright
Other

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