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Is ligation the only solution to the pyrophosphate problem?Pyrophosphate linkages are easily formed during the nonenzymatic oligomerization of activated nucleotides. They often form `caps' which terminate an oligonucleotide with a 5'-5' pyrophosphate. Owing to their structural resemblance to the intermediates in enzymatic ligation reactions, it has been suggested that pyrophosphate caps might have been capable of acting as activating groups in chain elongation processes. We argue that an alternative possibility would have been the specific hydrolysis of pyrophosphates.
Document ID
19950040952
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Visscher, J.
(Nijmegen Univ. Nijmegon, Netherlands)
Jongbloets, R.
(Nijmegen Univ. Nijmegon, Netherlands)
Schwartz, Alan W.
(Nijmegen Univ. Nijmegon, Netherlands)
Date Acquired
August 16, 2013
Publication Date
December 1, 1993
Publication Information
Publication: Origins of Life and Evolution of the Biosphere
Volume: 23
Issue: 6-May
ISSN: 0169-6149
Subject Category
Life Sciences (General)
Accession Number
95A72551
Funding Number(s)
CONTRACT_GRANT: NAGW-1660
Distribution Limits
Public
Copyright
Other

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