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Experiment K-7-18: Effects of Spaceflight in the Muscle Adductor Longus of Rats Flown in the Soviet Biosatellite Cosmos 2044Quantitative autoradiographic analysis of receptors for GABA and acetylcholine in the forebrain of rats flown on COSMOS 2044 was undertaken as part of a joint US-Soviet study to determine the effects of microgravity on the central nervous system, and in particular on the sensory and motor portions of the forebrain. Changes in binding of these receptors in tissue from animals exposed to microgravity would provide evidence for possible changes in neural processing as a result of exposure to microgravity. Tritium-labelled diazepam and Quinuclidinyl-benzilate (QNB) were used to visualize GABA (benzodiazepine) and muscarinic (cholinergic) receptors, respectively. The density of tritium-labelled radioligands bound to various regions in the forebrain of both flight and control animals were measured from autoradiograms. Data from rats flown in space and from ground-based control animals that were not exposed to microgravity were compared.
Document ID
19960028993
Acquisition Source
Ames Research Center
Document Type
Other
Authors
Wu, L.
(NASA Moffett Field, CA United States)
Daunton, N. G.
(NASA Moffett Field, CA United States)
Krasnov, I. B.
(Institute of Biomedical Problems Moscow, USSR)
DAmelio, F.
(NASA Moffett Field, CA United States)
Hyde, T. M.
(National Inst. of Mental Health Bethesda, MD United States)
Sigworth, S. K.
(National Inst. of Mental Health Bethesda, MD United States)
Date Acquired
August 17, 2013
Publication Date
September 1, 1994
Publication Information
Publication: US Experiments Flown on the Soviet Biosatellite Cosmos 2044
Subject Category
Life Sciences (General)
Accession Number
96N29588
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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