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S-Ketoprofen Inhibits Tenotomy-Induced Bone Loss and Dynamics in Weanling RatsThe objects of this study were to determine whether S-ketoprofen, a non-steroidal anti-inflammatory drug (NSAID), can prevent immobilization (tenotomy)-induced bone loss in weanling rats. Forty five 4 week-old Sprague-Dawley female rats were either sham-operated or subjected to knee tenotomy and treated simultaneously with 0, 0.02, 0.1, 0.5 or 2.5 mg of S-ketoprofen/kg per day for 21 days. We then studied double-fluorescent labeled proximal tibial longitudinal sections and tibial shaft cross sections using static and dynamic histomorphometry. Less cancellous bone mass in proximal tibial metaphyses was found in tenotomized controls than in basal (36%) and sham-operated (54%) controls. This was due to the inhibition of age-related bone gain and induced bone loss due to increased bone resorption and decreased bone formation. S-ketoprofen prevented both the inhibition of age-related bone gain and the stimulation of bone loss at the 2.5 mg/kg per day dose level, while it only prevented bone loss at the 0.5 mg/kg dose levels. In cancellous bone, dynamic histomorphometry showed that S-ketoprofen prevented the tenotomy induced decrease in bone formation and increase in bone resorption. In the tibial shaft, tenotomy inhibited the enlargement of total tissue area by depressing periosteal bone formation, and thus inhibited age-related cortical bone gain. S-ketoprofen treatment did not prevent this change at all dose levels, but reduced marrow cavity area to increase cortical bone area at the 0.1, 0.5 and 2.5 mg/kg per dose levels compared to tenotomy controls. However, the cortical bone area in the 0.1 and 0.5 mg dose-treated treated tenotomy rats was still lower than in the age-related controls. S-ketoprofen also prevented the increase in endocortical eroded perimeter induced by tenotomy. In summary, tenotomy inhibited age-related bone gain and stimulated bone loss in cancellous bone sites, and only inhibited age-related bone gain in cortical bone sites. S-ketoprofen treatment at the highest dose levels prevented the changes in cancellous bone, and reduced marrow area to increase cortical bone in the tibial shafts.
Document ID
19970003036
Acquisition Source
Ames Research Center
Document Type
Reprint (Version printed in journal)
Authors
Zeng, Q. Q.
(Utah Univ. Salt Lake City, UT United States)
Jee, W. S. S.
(Utah Univ. Salt Lake City, UT United States)
Ke, H. Z.
(Utah Univ. Salt Lake City, UT United States)
Wechter, W. J.
(Loma Linda Univ. CA United States)
Date Acquired
August 17, 2013
Publication Date
January 1, 1993
Publication Information
Publication: Bone and Mineral
Volume: 21
ISSN: 0169-6009
Subject Category
Life Sciences (General)
Report/Patent Number
NAS 1.26:202478
NASA-CR-202478
Accession Number
97N70180
Funding Number(s)
CONTRACT_GRANT: NAG2-435
Distribution Limits
Public
Copyright
Public Use Permitted.
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