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Long-term anabolic effects of prostaglandin-E2 on tibial diaphyseal bone in male ratsThe effects of long-term prostaglandin E2 (PGE2) on tibial diaphyseal bone were studied in 7-month-old male Sprague-Dawley rats given daily subcutaneous injections of 0, 1, 3 and 6 mg PGE2/kg/day for 60, 120 and 180 days. The tibial shaft was measured by single photon absorptiometry and dynamic histomorphometric analyses were performed on double-fluorescent labeled undecalcified tibial diaphyseal bone samples. Exogenous PGE2 administration produced the following transient changes in a dose-response manner between zero and 60 days: (1) increased bone width and mineral density; (2) increased total tissue and total bone areas; (3) decreased marrow area; (4) increased periosteal and corticoendosteal lamellar bone formation; (5) activated corticoendosteal lamellar and woven trabecular bone formation; and (6) activated intracortical bone remodeling. A new steady-state of increased tibial diaphyseal bone mass and elevated bone activities were observed from day 60 onward. The elevated bone mass level attained after 60 days of PGE2 treatment was maintained at 120 and 180 days. These observations indicate that the powerful anabolic effects of PGE2 will increase both periosteal and corticoendosteal bone mass and sustain the transient increase in bone mass with continuous daily administration of PGE2.
Document ID
19970003818
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Jee, Webster S. S.
(Utah Univ. Salt Lake City, UT United States)
Ke, Hua Zhu
(Utah Univ. Salt Lake City, UT United States)
Li, Xiao Jian
(Utah Univ. Salt Lake City, UT United States)
Date Acquired
August 17, 2013
Publication Date
January 1, 1991
Publication Information
Publication: Bone and Mineral
Publisher: Elsevier Science Publishers B.V.
Volume: 15
ISSN: 0169-6009
Subject Category
Life Sciences (General)
Report/Patent Number
BAM-00396
NAS 1.26:202672
NASA-CR-202672
Accession Number
97N70271
Funding Number(s)
CONTRACT_GRANT: DE-AC02-76EV-00119
CONTRACT_GRANT: DE-FG02-89ER-60764
CONTRACT_GRANT: NIH-AR-38346
CONTRACT_GRANT: NAG2-4235
Distribution Limits
Public
Copyright
Public Use Permitted.
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