NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Effectiveness of Botulinum Toxin Administered to Abolish Acquired NystagmusWe injected botulinum toxin into the horizontal rectus muscles of the right eyes of two patients who had acquired pendular nystagmus with horizontal, vertical, and torsional components. This treatment successfully abolished the horizontal component of the nystagmus in the injected eye in both patients for approximately 2 months. Both patients showed a small but measurable improvement of vision in the injected eye that may have been limited by coexistent disease of the visual pathways. The vertical and torsional components of the nystagmus persisted in both patients. In one patient, the horizontal component of nystagmus in the noninjected eye increased; we ascribe this finding to plastic-adaptive changes in response to paresis caused by the botulinum toxin. Such plastic-adaptive changes and direct side effects of the injections - such as diplopia and ptosis - may limit the effectiveness of botulinum toxin in the treatment of acquired nystagmus. Neither patient elected to repeat the botulinum treatment.
Document ID
19970016399
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Leigh, R. John
(Case Western Reserve Univ. Cleveland, OH United States)
Tomsak, Robert L.
(Case Western Reserve Univ. Cleveland, OH United States)
Grant, Michael P.
(Case Western Reserve Univ. Cleveland, OH United States)
Remler, Bernd F.
(Case Western Reserve Univ. Cleveland, OH United States)
Yaniglos, Stacy S.
(Case Western Reserve Univ. Cleveland, OH United States)
Lystad, Lisa
(Case Western Reserve Univ. Cleveland, OH United States)
Dell'Osso, Louis F.
(Case Western Reserve Univ. Cleveland, OH United States)
Date Acquired
August 17, 2013
Publication Date
November 1, 1992
Publication Information
Publication: Annals of Neurology
Publisher: Little, Brown and Company
Volume: 32
Issue: 5
Subject Category
Aerospace Medicine
Report/Patent Number
NASA-CR-204291
NAS 1.26:204291
Accession Number
97N71501
Funding Number(s)
CONTRACT_GRANT: NAG9-571
CONTRACT_GRANT: NIH-EY-06717
Distribution Limits
Public
Copyright
Public Use Permitted.
Document Inquiry

Available Downloads

There are no available downloads for this record.
No Preview Available