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Aspirin- and Indomethacin-Induced Ulcers and their Antagonism by AnthihistaminesGastric ulceration produced by aspirin and indomethacin was compared in acutely stressed and non-stressed rats. We found a synergism between these anti-inflammatory agents and acute stress in the production of gastric ulcers. Even at relatively high doses, neither agent caused appreciable gastric damage in non-stressed rats, whereas moderate doses of both agents produced massive ulceration in stressed rats. The synergism appears unrelated to the effect of these agents on the pituitary-adrenal response. The size and regional distribution of ulcers produced by aspirin and indomethacin in stressed rats were comparable. However, the dose--response curves of the two drugs were markedly dissimilar. Furthermore, the ulceration produced by indomethacin was attenuated by both H(sub 1) and H(sub 2) histamine receptor antagonists, whereas ulceration produced by aspirin was attenuated only by an H(sub 2) antagonist. The results suggest that the ulcerogenic mechanism of indomethacin may differ from that of aspirin and add to the growing evidence on the importance of endogenous histamine in various forms of gastric ulceration.
Document ID
19990054406
Acquisition Source
Ames Research Center
Document Type
Reprint (Version printed in journal)
Authors
Brown, Patricia A.
(NASA Ames Research Center Moffett Field, CA United States)
Sawrey, James M.
(NASA Ames Research Center Moffett Field, CA United States)
Vernikos, Joan
(NASA Ames Research Center Moffett Field, CA United States)
Date Acquired
August 19, 2013
Publication Date
January 1, 1978
Publication Information
Publication: European Journal of Pharmacology
Publisher: Elsevier/North Holland Biomedical Press
Volume: 51
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other

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