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Stress, Aging and ThirstAfter growth during adolesence, total body water decreases progressively with aging from 65% of body weight to about 53% of body weight in the 70th decade; a majority of the loss occurs from the extracellular volume, from 42% to about 25%, respectively. Cellular volume also reaches equilibrium in the 70th decade at about 25% of body weight. Various stresses such as exercise, heat and attitude exposure, ad prior dehydration attenuate voluntary fluid intake (involuntary dehydration). Voluntary fluid intake appears to decrease with aging (involuntary dehydration in this sense aging can be considered as a stress. Kidney function and muscle mass (80% water) decrease somewhat with aging, and voluntary fluid intake (thirst) is also attenuated. Thirst is stimulated by increasing osmolality (hypernatremia) of the extracellular fluid and by decreased extracellular volume (mainly plasma volume) which act to increase intracellular fluid volume osmolality to activiate drinking. The latter decreases fluid compartment osmolality which ' It terminates drinking. However, this drinking mechanism seems to be attenuated with aging such that increasing plasma osmolality no longer stimulates fluid intake appropriately. Hypernatremia in the elderly has been associated all too frequently with greater incidence of bacterial infection and increased mortality. Involuntary dehydration can be overcome in young men by acclimation to an intermittent exercise-in-heat training program. Perhaps exercise training in the elderly would also increase voluntary fluid intake and increase muscle mass to enhance retention of water.
Document ID
20000075211
Acquisition Source
Ames Research Center
Document Type
Reprint (Version printed in journal)
Authors
Greenleaf, John E.
(NASA Ames Research Center Moffett Field, CA United States)
Date Acquired
August 19, 2013
Publication Date
January 1, 1998
Publication Information
Publication: Facts, Research and Intervention in Geriatrics, 1998: Hydration and Aging
Publisher: Springer Publishing Co.
ISBN: 2-909342-52-2
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other

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