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Dietary Sodium Effects on Bone Loss and Calcium Metabolism During Bed RestThe acceleration of age-related bone loss is one of the most detrimental effects of space flight. The ability to understand and counteract this loss will be critical for crew health and safety during and after long-duration missions. Studies in healthy ambulatory individuals have linked high salt (sodium) diets, hypercalciuria, and increased renal stone risk. Dietary salt may modulate bone loss through changes in calcium metabolism and the calcium endocrine system. The research proposed here will determine the role of dietary salt in the loss of bone during simulated space flight. Calcium metabolism will be determined through calcium kinetics studies, endocrine and biochemical measurements; and estimates of the mass, distribution and mechanical properties of bone, in subjects fed low (100 mmol sodium/day) or high (250 mmol sodium/day) levels of dietary salt during 28 days of headdown tilt bedrest. This research addresses the role of dietary salt in the loss of bone and calcium in space flight, and integrates the changes in calcium metabolism with those occurring in other physiologic systems. These data will be critical for both countermeasure development, and in determination of nutritional requirements for extended-duration space flight. The potential countermeasures resulting from this research will reduce health risks due to acceleration of age-related osteoporosis and increased risk of renal stone formation..
Document ID
20000089880
Acquisition Source
Johnson Space Center
Document Type
Other
Authors
Smith, Scott M.
(NASA Johnson Space Center Houston, TX United States)
Arnaud, Sara B.
(NASA Ames Research Center Moffett Field, CA United States)
Abrams, Steven A.
(Baylor Coll. of Medicine Houston, TX United States)
Paloski, W. H.
Date Acquired
August 19, 2013
Publication Date
January 1, 2000
Subject Category
Aerospace Medicine
Report/Patent Number
NRA-99-HEDS-03
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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