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Quantifying Main Trends in Lysozyme Nucleation: The Effect of Precipitant Concentration and ImpuritiesFull factorial experiment design incorporating multi-linear regression analysis of the experimental data allows the main trends and effects to be quickly identified while using only a limited number of experiments. These techniques were used to identify the effect of precipitant concentration and the presence of an impurity, the physiological lysozyme dimer, on the nucleation rate and crystal dimensions of the tetragonal form of chicken egg white lysozyme. Increasing precipitant concentration was found to decrease crystal numbers, the magnitude of this effect also depending on the supersaturation. The presence of the dimer generally increased nucleation. The crystal axial ratio decreased with increasing precipitant concentration independent of impurity.
Document ID
20000110583
Acquisition Source
Marshall Space Flight Center
Document Type
Preprint (Draft being sent to journal)
Authors
Burke, Michael W.
(Alliance for Microgravity Materials Science and Applications Huntsville, AL United States)
Judge, Russell A.
(Alliance for Microgravity Materials Science and Applications Huntsville, AL United States)
Pusey, Marc L.
(NASA Marshall Space Flight Center Huntsville, AL United States)
Rose, M. Franklin
Date Acquired
August 19, 2013
Publication Date
January 1, 2000
Subject Category
Solid-State Physics
Funding Number(s)
CONTRACT_GRANT: NCC8-66
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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