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[Radiation Anticarcinogenesis by Thiazolidine Pro-drug]The original goal of this work was to determine the capacity of selected aminothiols to modulate radiation induced cytotoxicity, mutagenesis and carcinogenesis in a human mammary epithelial cell line. The conclusions from this work are that WR-1065 is the "gold standard" for protection against radiation induced cytotoxicity, mutagenesis and carcinogenesis. While a potent radiation protector, WR-1065 is cytotoxic in vitro and in vivo. Our rationale for a study of the thiazolidine pro-drugs was that these compounds are neither toxic in vitro or in vivo. The results obtained during this funding period indicate that the thiazolidine pro-drugs are as potent as WR-1065 as protectors against radiation induced mutation induction, and thus presumably against radiation induced carcinogenesis. Our results indicate that the thiazolidine prodrugs are excellent candidates to test as non-toxic anticarcinogens for protecting astronauts from cancer induction during space travel.
Document ID
20000112935
Acquisition Source
Goddard Space Flight Center
Document Type
Contractor or Grantee Report
Authors
Warters, Raymond L.
(Utah Univ. Salt Lake City, UT United States)
Roberts, Jeanette C.
(Utah Univ. Salt Lake City, UT United States)
Fain, Heidi
(Utah Univ. Salt Lake City, UT United States)
Date Acquired
August 19, 2013
Publication Date
January 1, 1999
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAG5-4452
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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