NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Plasma Hormone Concentrations in Monkeys after SpaceflightThe aim of this study was to determine the effects of a 12.5 day spaceflight on the endocrine status of Rhesus monkeys. Male monkeys (three to four years old; 4 kg) were adapted to chair restraint and trained for 20 months. Blood samples were obtained from four control (C) and two flight (F) monkeys preflight (PF), post-flight (Recovery-R; days 0, 3, 11, and 17), and before and after a mission length simulation (S). Cortisol, T4, T3, testosterone (T), and IGF-1 were measured by RIA (radioimmunassay). Growth hormone (GH) was measured by an in vitro bioassay. Cortisol (16-34 ug/dl), T4 (3.9-7.4 ug/dl), and T (0.2-0.4 mg/ml) did not differ between F and C or between PF, R, and S samples. The low T values reflect the immaturity of the animals. In F, T3 fell from C levels of 208 +/- 4 ng/dl to 44 on R+0 and 150 on R+3, then returned to C. F showed a 55% decrease in GH at R+0 and decreases of 93, 89, and 80%, respectively, at R+3, 11, and 17. IGF-1 decreased from PF levels of 675 ng/ml to 365 (R+0) and 243 (R+3), but returned to C at R+11. GH and IGF-1 levels before and after S did not differ from each other or from C. The cause of the transitory decrease in T3 is unknown. The suppressed GH levels for 17 days after flight may reflect reduced proprioceptive input during flight. The faster recovery of IGF-1 suggests that factors other than reduced GH secretion are involved.
Document ID
20020039851
Acquisition Source
Ames Research Center
Document Type
Conference Paper
Authors
Grindeland, Richard E.
(NASA Ames Research Center Moffett Field, CA United States)
Mukku, V. R.
Dotsenko, R.
Gosselink, K. L.
Bigbee, A. J.
Helwig, D.
Hargens, Alan R.
Date Acquired
August 20, 2013
Publication Date
January 1, 1997
Subject Category
Life Sciences (General)
Meeting Information
Meeting: FASEB Conference
Location: New Orleans, LA
Country: United States
Start Date: April 6, 1997
End Date: April 9, 1997
Sponsors: Federation of American Societies for Experimental Biology
Funding Number(s)
PROJECT: RTOP 199-26-09-12
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

Available Downloads

There are no available downloads for this record.
No Preview Available