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Alterations of Body Mass Gain of Neonates (P7&P14) During Certrifugation AT 2GPrevious research has shown animal body mass to be significantly affected by centrifugation. At the onset of centrifugation, animals have a selective loss of fat, causing an initial body mass loss. Body mass gain will resume at the same rate as uncentrifuged animals, but this subsequent gain will be lower. For this study, two different ages of Sprague Hawley neonate families were observed during centrifugation. Eight litters (dam with eight neonates) of postnatal day (PN) seven and four litters (dam with ten neonates) of PN 14 were separated into two separate groups each, centrifuge (+2G(sub z)) and environmental controls (EC) and placed into either the centrifuge or an animal holding unit in the centrifuge rotunda for a total of 16 days. P7: Total litter start mass of +2G(sub z) litter = 138.90 g/end = 311.0 g EC litter = 150.85 g/end = 516.9 g. P14: Total litter start mass of +2G(sub z) litter = 287.70 g/end = 762.5g; EC litter = 245 g/end = 942.9 g. An initial body mass loss was observed in both groups of +2G(sub z) animals for two days after the onset of centrifugation, but then an increase began to occur. Literature suggests adult animals at +2G(sub z), will have an initial loss, but will resume similar growth rates over time as compared to control animals. The P7 +2G(sub z) animals began to gain body mass, but showed a significantly slower growth rate than their EC animals for the duration of the test (pace). The P14 +2G(sub z) animals began to show similar growth rates to their EC after day nine. At day 16, both groups of +2Gz animals were significantly smaller than the EC animals (pace). At +2Gz, animals experience an initial body mass loss. Older animals are able to resume similar growth rates as their controls, but younger animals showed growth rates to be significantly reduced.
Document ID
20020040847
Acquisition Source
Ames Research Center
Document Type
Conference Paper
Authors
Baer, L. A.
Corbin, B. J.
Wade, C. E.
Hargens, Alan R.
Date Acquired
August 20, 2013
Publication Date
January 1, 1996
Subject Category
Life Sciences (General)
Meeting Information
Meeting: FASEB Conference
Location: New Orleans, LA
Country: United States
Start Date: April 6, 1997
End Date: April 9, 1997
Sponsors: Federation of American Societies for Experimental Biology
Funding Number(s)
CONTRACT_GRANT: NAS2-14263
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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