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Renal Response to Chronic Centrifugation in RatsPreviously reported effects of chronic centrifugation on renal function in mammals are contradictory. The present study was conducted as an effort to provide a comprehensive analysis of renal response to chronic centrifugation (12 days at +2 Gz). Sixteen male Sprague-Dawley rats (210-230 g) were used: eight centrifuged (EC) and eight off centrifuge controls (OCC). During centrifugation EC had lower body weight and food consumption. EC showed a decrease (72%) in water intake for the first two days (T1 and T2) followed by significant increases from T4-T6. EC urine output increased two-fold over the first four days, returning to baseline by T9. EC urea excretion was elevated on T3 through T5. Creatinine, Na(+), K(+), and osmolar excretion were lower than OCC over the last four days of the study. Assuming constant plasma osmolarity and creatinine levels, EC free water clearance (C(sub H2O)) was elevated significantly on T4 when the peak urine output was exhibited. EC also had a greater C(sub H2O) over the last four days, associated with a significantly lower osmolar clearance and GFR. The initial diuresis exhibited during centrifugation can be attributed to a reduced water resorption and increased urea excretion. This diuresis was mediated independent of changes in GFR over the first eight days. However, differences in excretion seen after eight days of centrifugation are probably GFR mediated which would imply animals established a new homeostatic setpoint by that time. Centrifugation elicites an acute alteration in fluid homeostasis followed by adaptation within a week.
Document ID
20020040954
Acquisition Source
Ames Research Center
Document Type
Conference Paper
Authors
Ortiz, Rudy M.
(NASA Ames Research Center Moffett Field, CA United States)
Wang, T. J.
(NASA Ames Research Center Moffett Field, CA United States)
Corbin, B. J.
(NASA Ames Research Center Moffett Field, CA United States)
Wade, C. E.
(NASA Ames Research Center Moffett Field, CA United States)
Hargens, Alan R.
Date Acquired
August 20, 2013
Publication Date
January 1, 1996
Subject Category
Life Sciences (General)
Meeting Information
Meeting: FASEB Conference
Location: New Orleans, LA
Country: United States
Start Date: April 6, 1997
End Date: April 9, 1997
Sponsors: Federation of American Societies for Experimental Biology
Funding Number(s)
PROJECT: RTOP 947-30-60
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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