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Phase Sensitive X-Ray Diffraction Imaging of Defects in Biological Macromolecular CrystalsCharacterization of defects and/or disorder in biological macromolecular crystals presents much greater challenges than in conventional small-molecule crystals. The lack of sufficient contrast of defects is often a limiting factor in x-ray diffraction topography of protein crystals. This has seriously hampered efforts to understand mechanisms and origins of formation of imperfections, and the role of defects as essential entities in the bulk of macromolecular crystals. In this report, we employ a phase sensitive x-ray diffraction imaging approach for augmenting the contrast of defects in protein crystals.
Document ID
20020068567
Acquisition Source
Marshall Space Flight Center
Document Type
Preprint (Draft being sent to journal)
Authors
Hu, Z. W.
(NASA Marshall Space Flight Center Huntsville, AL United States)
Lai, B.
(Argonne National Lab. IL United States)
Chu, Y. S.
(Argonne National Lab. IL United States)
Cai, Z.
(Argonne National Lab. IL United States)
Mancini, D. C.
(Argonne National Lab. IL United States)
Thomas, B. R.
(NASA Marshall Space Flight Center Huntsville, AL United States)
Chernov, A. A.
(NASA Marshall Space Flight Center Huntsville, AL United States)
Curreri, Peter A.
Date Acquired
August 20, 2013
Publication Date
January 1, 2002
Subject Category
Solid-State Physics
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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