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Pentopyranosyl Oligonucleotide SystemsTo determine whether the remarkable chemical properties of the pyranosyl isomer of RNA as an informational Watson-Crick base-pairing system are unique to the pentopyranosyl-(4 + 2)-oligonucleotide isomer derived from the RNA-building block D-ribose, studies on the entire family of diastereoisomeric pyranosyL(4 - Z)-oligonucleotide systems deriving from D-ribose. L-lyxose. D-xylose, and L-arabinose were carried out. The result of these extended studies is unambiguous: not only pyranosyl-RNA, but all members of the pentopyranosyl(4 + 2)-oligonucleotide family are highly efficient Watson-Crick base-pairing systems. Their synthesis and pairing properties will be described in a series of publications in this journal.
Document ID
20030068012
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Reck, Folkert
Kudick, Rene
Krishnamurthy, Ramanarayanan
Eschenmoser, Albert
Wippo, Harald
Date Acquired
August 21, 2013
Publication Date
January 1, 2001
Publication Information
Publication: Helvetica Chimica Acta
Volume: 84
Subject Category
Inorganic, Organic And Physical Chemistry
Funding Number(s)
CONTRACT_GRANT: NAG5-4546
Distribution Limits
Public
Copyright
Other

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