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Molecular Basis of Mechano-Signal Transduction in Vascular Endothelial CellsSimulated microgravity studies using a random positioning machine (RPM). One RPM machine has been built for us by Fokker Science in Netherland. Using the device, we have developed an in vitro system to examine the effect of simulated microgravity on osteoblastic bone cells. Using this system, we have carried out gene chip studies to determine the gene expression profiles of osteoblasts cultured under simulated microgravity conditions in comparison to static controls. From this study, we have identified numerous genes, some of which are expected ones inducing bone loss, but many of which are unexpected and unknown. These findings are being prepared for publications.
Document ID
20040030514
Acquisition Source
Headquarters
Document Type
Contractor or Grantee Report
Authors
Jo, Hanjoong
(Georgia Tech Research Inst. Atlanta, GA, United States)
Date Acquired
August 21, 2013
Publication Date
February 13, 2004
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAG2-1348
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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