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Mechanisms for Antagonistic Regulation of AMPA and NMDA-D1 Receptor Complexes at Postsynaptic SitesFrom the analysis of these pathways we conclude that postsynaptic processes that regulate synaptic transmission undergo significant cross-talk with respect to glutamatergic and neuromodulatory (dopamine) signals. The main hypothesis is that of a compensatory regulation, a competitive switch between the induction of increased AMPA conductance by CaMKII-dependent phosphorylation and reduced expression of PP2A, and increased D1 receptor sensitivity and expression by increased PKA, PP2A and decreased PP-1/calcineurin expression. Both types of plasticity are induced by NMDA receptor activation and increased internal calcium, they require different internal conditions to become expressed. Specifically we propose that AMPA regulation and D1 regulation are inversely coupled;The net result may be a bifurcation of synaptic state into predominantly AMPA or NMDA-D1 synapses. This could have functional consequences: stable connections for AMPA and conditional gating for NMDA-D1 synapses.
Document ID
20040077370
Acquisition Source
Ames Research Center
Document Type
Preprint (Draft being sent to journal)
Authors
Schumann, Johann
(Research Inst. for Advanced Computer Science Moffett Field, CA, United States)
Scheler, Gabriele
(ISLE Stanford, CA, United States)
Date Acquired
August 21, 2013
Publication Date
January 1, 2004
Subject Category
General
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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