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A computational model-based validation of Guyton's analysis of cardiac output and venous return curvesGuyton developed a popular approach for understanding the factors responsible for cardiac output (CO) regulation in which 1) the heart-lung unit and systemic circulation are independently characterized via CO and venous return (VR) curves, and 2) average CO and right atrial pressure (RAP) of the intact circulation are predicted by graphically intersecting the curves. However, this approach is virtually impossible to verify experimentally. We theoretically evaluated the approach with respect to a nonlinear, computational model of the pulsatile heart and circulation. We developed two sets of open circulation models to generate CO and VR curves, differing by the manner in which average RAP was varied. One set applied constant RAPs, while the other set applied pulsatile RAPs. Accurate prediction of intact, average CO and RAP was achieved only by intersecting the CO and VR curves generated with pulsatile RAPs because of the pulsatility and nonlinearity (e.g., systemic venous collapse) of the intact model. The CO and VR curves generated with pulsatile RAPs were also practically independent. This theoretical study therefore supports the validity of Guyton's graphical analysis.
Document ID
20040087424
Acquisition Source
Goddard Space Flight Center
Document Type
Reprint (Version printed in journal)
Authors
Mukkamala, R.
(Harvard-MIT Division of Health Sciences and Technology Cambridge, MA, United States)
Cohen, R. J.
Mark, R. G.
Date Acquired
August 21, 2013
Publication Date
January 1, 2002
Publication Information
Publication: Computers in cardiology
Volume: 29
ISSN: 0276-6574
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAG5-4989
CONTRACT_GRANT: P41-RR-13622
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
NASA Program Biomedical Research and Countermeasures
Non-NASA Center
Validation Studies

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