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Short-term adaptation of the VOR: non-retinal-slip error signals and saccade substitutionWe studied short-term (30 min) adaptation of the vestibulo-ocular reflex (VOR) in five normal humans using a "position error" stimulus without retinal image motion. Both before and after adaptation a velocity gain (peak slow-phase eye velocity/peak head velocity) and a position gain (total eye movement during chair rotation/amplitude of chair motion) were measured in darkness using search coils. The vestibular stimulus was a brief ( approximately 700 ms), 15 degrees chair rotation in darkness (peak velocity 43 degrees /s). To elicit adaptation, a straight-ahead fixation target disappeared during chair movement and when the chair stopped the target reappeared at a new location in front of the subject for gain-decrease (x0) adaptation, or 10 degrees opposite to chair motion for gain-increase (x1.67) adaptation. This position-error stimulus was effective at inducing VOR adaptation, though for gain-increase adaptation the primary strategy was to substitute augmenting saccades during rotation while for gain-decrease adaptation both corrective saccades and a decrease in slow-phase velocity occurred. Finally, the presence of the position-error signal alone, at the end of head rotation, without any attempt to fix upon it, was not sufficient to induce adaptation. Adaptation did occur, however, if the subject did make a saccade to the target after head rotation, or even if the subject paid attention to the new location of the target without actually looking at it.
Document ID
20040087449
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Eggers, Sscott D Z.
(The Johns Hopkins University School of Medicine Baltimore, Maryland 21287, United States)
De Pennington, Nick
Walker, Mark F.
Shelhamer, Mark
Zee, David S.
Date Acquired
August 21, 2013
Publication Date
October 1, 2003
Publication Information
Publication: Annals of the New York Academy of Sciences
Volume: 1004
ISSN: 0077-8923
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: R01-EY01849
CONTRACT_GRANT: R01 DC02849
CONTRACT_GRANT: K23-EY00400
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience
NASA Program Biomedical Research and Countermeasures

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