NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Noninvasive assessment of mitral inertness: clinical results with numerical model validationInertial forces (Mdv/dt) are a significant component of transmitral flow, but cannot be measured with Doppler echo. We validated a method of estimating Mdv/dt. Ten patients had a dual sensor transmitral (TM) catheter placed during cardiac surgery. Doppler and 2D echo was performed while acquiring LA and LV pressures. Mdv/dt was determined from the Bernoulli equation using Doppler velocities and TM gradients. Results were compared with numerical modeling. TM gradients (range: 1.04-14.24 mmHg) consisted of 74.0 +/- 11.0% inertial forcers (range: 0.6-12.9 mmHg). Multivariate analysis predicted Mdv/dt = -4.171(S/D (RATIO)) + 0.063(LAvolume-max) + 5. Using this equation, a strong relationship was obtained for the clinical dataset (y=0.98x - 0.045, r=0.90) and the results of numerical modeling (y=0.96x - 0.16, r=0.84). TM gradients are mainly inertial and, as validated by modeling, can be estimated with echocardiography.
Document ID
20040087459
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
Authors
Firstenberg, M. S.
(The Cleveland Clinic Foundation Cleveland, United States)
Greenberg, N. L.
Smedira, N. G.
McCarthy, P. M.
Garcia, M. J.
Thomas, J. D.
Date Acquired
August 21, 2013
Publication Date
January 1, 2001
Publication Information
Publication: Computers in cardiology
Volume: 28
ISSN: 0276-6574
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NCC9-58
CONTRACT_GRANT: 1R01HL56688-01A1
CONTRACT_GRANT: AHA 93-13880
CONTRACT_GRANT: NCC9-60
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cardiopulmonary
NASA Program Biomedical Research and Countermeasures
Validation Studies
Non-NASA Center

Available Downloads

There are no available downloads for this record.
No Preview Available