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Model-based parameter estimation using cardiovascular response to orthostatic stressThis paper presents a cardiovascular model that is capable of simulating the short-term (< or approximately equal to 3 min) transient hemodynamic response to gravitational stress and a gradient-based optimization method that allows for the automated estimation of model parameters from simulated or experimental data. We perform a sensitivity analysis of the transient heart rate response to determine which parameters of the model impact the heart rate dynamics significantly. We subsequently include only those parameters in the estimation routine that impact the transient heart rate dynamics substantially. We apply the estimation algorithm to both simulated and real data and showed that restriction to the 20 most important parameters does not impair our ability to match the data.
Document ID
20040087462
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
Authors
Heldt, T.
(Massachusetts Institute of Technology Cambridge, MA, United States)
Shim, E. B.
Kamm, R. D.
Mark, R. G.
Date Acquired
August 21, 2013
Publication Date
January 1, 2001
Publication Information
Publication: Computers in cardiology
Volume: 28
ISSN: 0276-6574
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NCC9-58
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Program Biomedical Research and Countermeasures
NASA Discipline Cardiopulmonary

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