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MRI of the lung gas-space at very low-field using hyperpolarized noble gasesIn hyperpolarized (HP) noble-gas magnetic resonance imaging, large nuclear spin polarizations, about 100,000 times that ordinarily obtainable at thermal equilibrium, are created in 3He and 129Xe. The enhanced signal that results can be employed in high-resolution MRI studies of void spaces such as in the lungs. In HP gas MRI the signal-to-noise ratio (SNR) depends only weakly on the static magnetic field (B(0)), making very low-field (VLF) MRI possible; indeed, it is possible to contemplate portable MRI using light-weight solenoids or permanent magnets. This article reports the first in vivo VLF MR images of the lungs in humans and in rats, obtained at a field of only 15 millitesla (150 Gauss).
Document ID
20040087491
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Venkatesh, Arvind K.
(Brigham and Women's Hospital and Harvard Medical School Boston, MA 02115, United States)
Zhang, Adelaide X.
Mansour, Joey
Kubatina, Lyubov
Oh, Chang Hyun
Blasche, Gregory
Selim Unlu, M.
Balamore, Dilip
Jolesz, Ferenc A.
Goldberg, Bennett B.
Albert, Mitchell S.
Date Acquired
August 21, 2013
Publication Date
September 1, 2003
Publication Information
Publication: Magnetic resonance imaging
Volume: 21
Issue: 7
ISSN: 0730-725X
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: R01-HL57563
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Life Sciences Technologies
NASA Program Biomedical Research and Countermeasures
Non-NASA Center

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