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Radiation-induced genomic instability and its implications for radiation carcinogenesisRadiation-induced genomic instability is characterized by an increased rate of genetic alterations including cytogenetic rearrangements, mutations, gene amplifications, transformation and cell death in the progeny of irradiated cells multiple generations after the initial insult. Chromosomal rearrangements are the best-characterized end point of radiation-induced genomic instability, and many of the rearrangements described are similar to those found in human cancers. Chromosome breakage syndromes are defined by chromosome instability, and individuals with these diseases are cancer prone. Consequently, chromosomal instability as a phenotype may underlie some fraction of those changes leading to cancer. Here we attempt to relate current knowledge regarding radiation-induced chromosome instability with the emerging molecular information on the chromosome breakage syndromes. The goal is to understand how genetic and epigenetic factors might influence the onset of chromosome instability and the role of chromosomal instability in carcinogenesis.
Document ID
20040087551
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Huang, Lei
(University of Maryland 655 W. Baltimore St., Baltimore, MD 21201-1559, United States)
Snyder, Andrew R.
Morgan, William F.
Date Acquired
August 21, 2013
Publication Date
September 1, 2003
Publication Information
Publication: Oncogene
Volume: 22
Issue: 37
ISSN: 0950-9232
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: CA 83872
CONTRACT_GRANT: CA73924
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
NASA Discipline Radiation Health
Review
Non-NASA Center

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