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Mechanical injury and repair of cellsOBJECTIVE: To concisely review the field of cell plasma membrane disruption (torn cell surface) and repair. MAIN POINTS: Plasma membrane disruption is a common form of cell injury under physiologic conditions, after trauma, in certain muscular dystrophies, and during certain forms of clinical intervention. Rapid repair of a disruption is essential to cell survival and involves a complex and active cell response that includes membrane fusion and cytoskeletal activation. Tissues, such as cardiac and skeletal muscle, adapt to a disruption injury by hypertrophying. Cells adapt by increasing the efficiency of their resealing response. CONCLUSION: Plasma membrane disruption is an important cellular event in both health and disease. The disruption repair mechanism is now well understood at the cellular level, but much remains to be learned at the molecular level. Cell and tissue level adaptational responses to the disruption either prevent its further occurrence or facilitate future repairs. Therapeutically useful drugs might result if, using this accumulating knowledge, chemical agents can be developed that can enhance repair or adaptive responses.
Document ID
20040087567
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Miyake, Katsuya
(Department of Cellular Biology and Anatomy and the Institute of Molecular Medicine and Genetics, Medical College of Georgia Augusta, 30912, United States)
McNeil, Paul L.
Date Acquired
August 21, 2013
Publication Date
August 1, 2003
Publication Information
Publication: Critical care medicine
Volume: 31
Issue: 8 Suppl
ISSN: 0090-3493
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
Non-NASA Center
Review
NASA Discipline Cell Biology

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