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Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ionsThe frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.
Document ID
20040087649
Acquisition Source
Johnson Space Center
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Kawata, Tetsuya
(Graduate School of Medicine, Chiba University 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan)
Ito, Hisao
Motoori, Ken
Ueda, Takuya
Shigematsu, Naoyuki
Furusawa, Yoshiya
Durante, Marco
George, Kerry
Wu, Honglu
Cucinotta, Francis A.
Date Acquired
August 21, 2013
Publication Date
December 1, 2002
Publication Information
Publication: Journal of radiation research
Volume: 43 Suppl
ISSN: 0449-3060
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Center JSC
NASA Discipline Radiation Health

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