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Development of vestibular afferent projections into the hindbrain and their central targetsIn contrast to most other sensory systems, hardly anything is known about the neuroanatomical development of central projections of primary vestibular neurons and how their second order target neurons develop. Recent data suggest that afferent projections may develop not unlike other sensory systems, forming first the overall projection by molecular means followed by an as yet unspecified phase of activity mediated refinement. The latter aspect has not been tested critically and most molecules that guide the initial projection are unknown.The molecular and topological origin of the vestibular and cochlear nucleus neurons is also only partially understood. Auditory and vestibular nuclei form from several rhombomeres and a given rhombomere can contribute to two or more auditory or vestibular nuclei. Rhombomere compartments develop as functional subdivisions from a single column that extends from the hindbrain to the spinal cord. Suggestions are provided for the molecular origin of these columns but data on specific mutants testing these proposals are not yet available. Overall, the functional significance of both overlapping and segregated projections are not yet fully experimentally explored in mammals. Such lack of details of the adult organization compromises future developmental analysis.
Document ID
20040087663
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Maklad, Adel
(Creighton University Omaha, NE 68178, United States)
Fritzsch, Bernd
Date Acquired
August 21, 2013
Publication Date
June 15, 2003
Publication Information
Publication: Brain research bulletin
Volume: 60
Issue: 6-May
ISSN: 0361-9230
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: 2P01 DC00215
CONTRACT_GRANT: R01 DC005590
Distribution Limits
Public
Copyright
Other
Keywords
Review
NASA Discipline Developmental Biology
Review, Academic
Non-NASA Center

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