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Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epitheliumCyclooxygenase-2 (COX-2) is emerging as an important cancer biomarker and is now an experimental target for solid tumor treatment.However, no study has exclusively focused on COX-2 expression in early lesions such as ductal carcinoma in situ (DCIS). We examined COX-2 expression by immunohistochemistry in 46 cases of women undergoing surgical resection for DCIS. We found that COX-2 expression was detected in 85% of all DCIS specimens, with increased COX-2 staining correlating with higher nuclear grade. Strikingly, COX-2 staining intensity in the normal adjacent epithelium was stronger than in the DCIS lesion itself. Our observations demonstrate that COX-2 is up-regulated in the normal adjacent epithelium and supports the hypothesis that the surrounding epithelial tissue is part of the disease process in DCIS.
Document ID
20040087693
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Shim, Veronica
(University of California at San Francisco Comprehensive Cancer Center, University of California San Francisco, California 94115-1710, United States)
Gauthier, Mona L.
Sudilovsky, Daniel
Mantei, Kristin
Chew, Karen L.
Moore, Dan H.
Cha, Imok
Tlsty, Thea D.
Esserman, Laura J.
Date Acquired
August 21, 2013
Publication Date
May 15, 2003
Publication Information
Publication: Cancer research
Volume: 63
Issue: 10
ISSN: 0008-5472
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: CA73952
CONTRACT_GRANT: P30CA 82103-01
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Radiation Health
Non-NASA Center

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