NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Basic and clinical immunologyProgress in immunology continues to grow exponentially every year. New applications of this knowledge are being developed for a broad range of clinical conditions. Conversely, the study of primary and secondary immunodeficiencies is helping to elucidate the intricate mechanisms of the immune system. We have selected a few of the most significant contributions to the fields of basic and clinical immunology published between October 2001 and October 2002. Our choice of topics in basic immunology included the description of T-bet as a determinant factor for T(H)1 differentiation, the role of the activation-induced cytosine deaminase gene in B-cell development, the characterization of CD4(+)CD25(+) regulatory T cells, and the use of dynamic imaging to study MHC class II transport and T-cell and dendritic cell membrane interactions. Articles related to clinical immunology that were selected for review include the description of immunodeficiency caused by caspase 8 deficiency; a case series report on X-linked agammaglobulinemia; the mechanism of action, efficacy, and complications of intravenous immunoglobulin; mechanisms of autoimmunity diseases; and advances in HIV pathogenesis and vaccine development. We also reviewed two articles that explore the possible alterations of the immune system caused by spaceflights, a new field with increasing importance as human space expeditions become a reality in the 21st century.
Document ID
20040087808
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Chinen, Javier
(National Human Genome Research Institute Bethesda, MD, United States)
Shearer, William T.
Date Acquired
August 21, 2013
Publication Date
March 1, 2003
Publication Information
Publication: The Journal of allergy and clinical immunology
Volume: 111
Issue: 3 Suppl
ISSN: 0091-6749
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review
Non-NASA Center
Review, Tutorial
NASA Discipline Regulatory Physiology

Available Downloads

There are no available downloads for this record.
No Preview Available