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Partial segregation of posterior crista and saccular fibers to the nodulus and uvula of the cerebellum in mice, and its developmentThe projection of the posterior canal crista and saccular afferents to the cerebellum of embryonic and neonatal mice was investigated using carbocyanine dyes. Anterograde tracing from these two endorgans reveals a partial segregation of these two sets of afferents. The saccule projects predominantly to the uvula, with very minor input to the nodulus. The posterior canal projects mainly to the nodulus and, to a lesser extent, to the uvula. Retrograde tracing from the uvula and nodulus confirms this partial segregation for these two endorgans and extends it to other vestibular endorgans. Uvular injections result in many more labeled fibers in the gravistatic maculae than in the canals' cristae. In contrast, nodular injection reveals many more labeled fibers in the canal cristae than in the gravistatic maculae. This partial segregation may play a role in the information processing in these folia. Our developmental data suggest that the initial segregation at E17 coincides with the formation of the postero-lateral fissure. This embryonic segregation of the primary vestibular mossy fibers to the uvula and nodulus commences long before the maturity of their targets, the granule cells and unipolar brush cells. Thus, the segregation of the primary vestibular projection to the uvula and nodulus does not depend on cues related to the target cells. Rather, the segregation may reflect more global cerebellar patterning mechanisms involving guidance for the vestibular afferent fibers independent of the future target cells.
Document ID
20040087839
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Maklad, Adel
(Creighton University School of Medicine 2500 California Plaza, Omaha, NE 68178, United States)
Fritzsch, Bernd
Date Acquired
August 21, 2013
Publication Date
February 16, 2003
Publication Information
Publication: Brain research. Developmental brain research
Volume: 140
Issue: 2
ISSN: 0165-3806
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: 2P01DC00215
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Developmental Biology

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