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Hormonal changes during 17 days of head-down bed-restWe investigated in six men the impact of 17 days of head-down bed rest (HDBR) on the daily rhythms of the hormones involved in hydroelectrolytic regulation. This HDBR study was designed to mimic a real space flight. Urine samples were collected at each voiding before, during and after HDBR. Urinary excretion of Growth Hormone (GH), Cortisol, 6 Sulfatoxymelatonin, Normetadrenaline (NMN) and Metadrenaline (NM) was determined. A decrease in urinary cortisol excretion during the night of HDBR was noted. For GH, a rhythm was found before and during HDBR. The rhythm of melatonin, evaluated with the urine excretion of 6 Sulfatoxymelatonin (aMT6S), the main hepatic metabolite, persisted throughout the experiment without any modification to the level of phase. A decrease during the night was noted for normetadrenaline urinary derivates, but only during the HDBR.
Document ID
20040087924
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Custaud, Marc-Antoine
(Faculte de Medecine Lyon Grange-Blanche 8 Avenue Rockefeller, F-69373 Lyon Cedex 08, France)
Arnaud, Sara B.
Monk, Timothy H.
Claustrat, Bruno
Gharib, Claude
Gauquelin-Koch, Guillemette
Date Acquired
August 21, 2013
Publication Date
January 17, 2003
Publication Information
Publication: Life sciences
Volume: 72
Issue: 9
ISSN: 0024-3205
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Center ARC
NASA Discipline Regulatory Physiology

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