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Skeletal muscle plasticity: cellular and molecular responses to altered physical activity paradigmsThe goal of this article is to examine our current understanding of the chain of events known to be involved in the adaptive process whereby specific genes and their protein products undergo altered expression; specifically, skeletal muscle adaptation in response to altered loading states will be discussed, with a special focus on the regulation of the contractile protein, myosin heavy chain gene expression. This protein, which is both an important structural and regulatory protein comprising the contractile apparatus, can be expressed as different isoforms, thereby having an impact on the functional diversity of the muscle. Because the regulation of the myosin gene family is under the control of a complex set of processes including, but not limited to, activity, hormonal, and metabolic factors, this protein will serve as a cellular "marker" for studies of muscle plasticity in response to various mechanical perturbations in which the quantity and type of myosin isoform, along with other important cellular proteins, are altered in expression.
Document ID
20040088012
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Baldwin, Kenneth M.
(University of California-Irvine Irvine, CA 92697-4560, United States)
Haddad, Fadia
Date Acquired
August 21, 2013
Publication Date
November 1, 2002
Publication Information
Publication: American journal of physical medicine & rehabilitation / Association of Academic Physiatrists
Volume: 81
Issue: 11 Suppl
ISSN: 0894-9115
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AR 30346
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal
Review
Review, Tutorial

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