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The AMPA receptor subunit GluR1 regulates dendritic architecture of motor neuronsThe morphology of the mature motor neuron dendritic arbor is determined by activity-dependent processes occurring during a critical period in early postnatal life. The abundance of the AMPA receptor subunit GluR1 in motor neurons is very high during this period and subsequently falls to a negligible level. To test the role of GluR1 in dendrite morphogenesis, we reintroduced GluR1 into rat motor neurons at the end of the critical period and quantitatively studied the effects on dendrite architecture. Two versions of GluR1 were studied that differed by the amino acid in the "Q/R" editing site. The amino acid occupying this site determines single-channel conductance, ionic permeability, and other essential electrophysiologic properties of the resulting receptor channels. We found large-scale remodeling of dendritic architectures in a manner depending on the amino acid occupying the Q/R editing site. Alterations in the distribution of dendritic arbor were not prevented by blocking NMDA receptors. These observations suggest that the expression of GluR1 in motor neurons modulates a component of the molecular substrate of activity-dependent dendrite morphogenesis. The control of these events relies on subunit-specific properties of AMPA receptors.
Document ID
20040088132
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Inglis, Fiona M.
(Yale University School of Medicine New Haven, Connecticut 06520-8018, United States)
Crockett, Richard
Korada, Sailaja
Abraham, Wickliffe C.
Hollmann, Michael
Kalb, Robert G.
Date Acquired
August 21, 2013
Publication Date
September 15, 2002
Publication Information
Publication: The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume: 22
Issue: 18
ISSN: 0270-6474
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NS33467
CONTRACT_GRANT: NS29837
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cell Biology

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