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Nonhereditary enhancement of progeny growthThe im electroporated injection of a protease-resistant GH-releasing hormone cDNA into rat dams at 16 d gestation resulted in enhanced long-term growth of the F(1) offspring. The offspring were significantly heavier by 2 wk of age, and the difference was sustained to 10 wk of age. Consistent with their augmented growth, the plasma IGF-I concentration of the F(1) progeny was increased significantly. The pituitary gland of the offspring was significantly heavier and contained an increased number of somatotrophs and PRL-secreting cells, which is indicative of modification of cell lineage differentiation. These unique findings demonstrate that enhanced GH-releasing hormone expression in pregnant dams can result in intergenerational growth promotion by altering development of the pituitary gland in the offspring.
Document ID
20040088164
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Khan, Amir S.
(Baylor College of Medicine Houston, Texas 77030, United States)
Fiorotto, Marta L.
Hill, Leigh-Anne
Malone, P. Brandon
Cummings, Kathleen K.
Parghi, Deena
Schwartz, Robert J.
Smith, Roy G.
Draghia-Akli, Ruxandra
Date Acquired
August 21, 2013
Publication Date
September 1, 2002
Publication Information
Publication: Endocrinology
Volume: 143
Issue: 9
ISSN: 0013-7227
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DK-07696
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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