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Is the spatial distribution of brain lesions associated with closed-head injury in children predictive of subsequent development of posttraumatic stress disorder?PURPOSE: To determine whether there is an association between the spatial distributions of lesions detected at magnetic resonance (MR) imaging of the brain in children, adolescents, and young adults after closed-head injury (CHI) and development of the reexperiencing symptoms of posttraumatic stress disorder (PTSD). MATERIALS AND METHODS: Data obtained in 94 subjects without a history of PTSD as determined by parental interview were analyzed. MR images were obtained 3 months after CHI. Lesions were manually delineated and registered to the Talairach coordinate system. Mann-Whitney analysis of lesion distribution and PTSD status at 1 year (again, as determined by parental interview) was performed, consisting of an analysis of lesion distribution versus the major symptoms of PTSD: reexperiencing, hyperarousal, and avoidance. RESULTS: Of the 94 subjects, 41 met the PTSD reexperiencing criterion and nine met all three PTSD criteria. Subjects who met the reexperiencing criterion had fewer lesions in limbic system structures (eg, the cingulum) on the right than did subjects who did not meet this criterion (Mann-Whitney, P =.003). CONCLUSION: Lesions induced by CHI in the limbic system on the right may inhibit subsequent manifestation of PTSD reexperiencing symptoms in children, adolescents, and young adults. Copyright RSNA, 2002.
Document ID
20040088198
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Herskovits, Edward H.
(Johns Hopkins Medical Institutions 600 N Wolfe St, Baltimore, MD 21287-7619, United States)
Gerring, Joan P.
Davatzikos, Christos
Bryan, R. Nick
Date Acquired
August 21, 2013
Publication Date
August 1, 2002
Publication Information
Publication: Radiology
Volume: 224
Issue: 2
ISSN: 0033-8419
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: R01 AG13743
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience

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