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Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neuronsReceptors for the Fc portion of immunoglobulin G (IgG; FcgammaRs) facilitate IgG uptake by effector cells as well as cellular responses initiated by IgG binding. In earlier studies, we demonstrated that amyotrophic lateral sclerosis (ALS) patient IgG can be taken up by motor neuron terminals and transported retrogradely to the cell body and can alter the function of neuromuscular synapses, such as increasing intracellular calcium and spontaneous transmitter release from motor axon terminals after passive transfer. In the present study, we examined whether FcgammaR-mediated processes can contribute to these effects of ALS patient immunoglobulins. F(ab')(2) fragments (which lack the Fc portion) of ALS patient IgG were not taken up by motor axon terminals and were not retrogradely transported. Furthermore, in a genetically modified mouse lacking the gamma subunit of the FcR, the uptake of whole ALS IgG and its ability to enhance intracellular calcium and acetylcholine release were markedly attenuated. These data suggest that FcgammaRs appear to participate in IgG uptake into motor neurons as well as IgG-mediated increases in intracellular calcium and acetylcholine release from motor axon terminals. Copyright 2002 Wiley-Liss, Inc.
Document ID
20040088233
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Mohamed, Habib A.
(Baylor College of Medicine Houston, Texas 77030, United States)
Mosier, Dennis R.
Zou, Ling L.
Siklos, Laszlo
Alexianu, Maria E.
Engelhardt, Jozsef I.
Beers, David R.
Le, Wei-dong
Appel, Stanley H.
Date Acquired
August 21, 2013
Publication Date
July 1, 2002
Publication Information
Publication: Journal of neuroscience research
Volume: 69
Issue: 1
ISSN: 0360-4012
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NS 01859
CONTRACT_GRANT: AR 38970
CONTRACT_GRANT: NS 33186
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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