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Effects of major histocompatibility complex class II knockout on mouse bone mechanical properties during developmentWe investigated the effect of major histocompatibility complex class II (MHC II) knockout on the development of the mouse peripheral skeleton. These C2D mice had less skeletal development at 8, 12 and 16 weeks of age compared to wild-type C57BL/6J (B6) male mice. The C2D mice had decreased femur mechanical, geometric and compositional measurements compared to wild type mice at each of these ages. C2D femur stiffness (S), peak force in 3-pt bending (Pm), and mineral mass (Min-M) were 74%, 64% and 66%, respectively, of corresponding B6 values at 8 weeks of age. Similar differences were measured at 12 weeks (for which C2D femoral S, Pm and Min-M were 71%, 72% and 73%, respectively, of corresponding B6 values) and at 16 weeks (for which C2D femoral S, Pm and Min-M were 80%, 66% and 61%, respectively, of corresponding B6 values). MHC II knockout delays the development of adult bone properties and is accompanied by lower body mass compared to wild-type controls.
Document ID
20040088251
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Simske, Steven J.
(Univ. Colorado Campus Box 429, Boulder, CO 80309, United States)
Bateman, Ted A.
Smith, Erin E.
Ferguson, Virginia L.
Chapes, Stephen K.
Date Acquired
August 21, 2013
Publication Date
January 1, 2002
Publication Information
Publication: Biomedical sciences instrumentation
Volume: 38
ISSN: 0067-8856
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cell Biology

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