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Effects of chair restraint on the strength of the tibia in rhesus monkeysTo determine the effects of the relative inactivity and unloading on the strength of the tibias of monkeys, Macaca mulatta, we used a non-invasive test to measure bending stiffness, or EI (Nm2), a mechanical property. The technique was validated by comparisons of in vivo measurements with standard measures of EI in the same bones post-mortem (r2 = 0.95, P < 0.0001). Inter-test precision was 4.28+/-1.4%. Normative data in 24 monkeys, 3.0+/-0.7 years and 3.6+/-0.6 kg, revealed EI to be 16% higher in the right than left tibia (4.4+/-1.6 vs. 3.7+/-1.6 Nm2, P < 0.05). Five monkeys, restrained in chairs for 14 days, showed decreases in EI. There were no changes in EI in two chaired monkeys that lost weight during a 2-week space flight. The factors that account for both the decreases in bone mechanical properties after chair restraint at 1 g and lack of change after microgravity remain to be identified. Metabolic factors associated with body weight changes are suggested by our results.
Document ID
20040088345
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hutchinson, T. M.
(NASA Ames Research Center Moffett Field CA United States)
Bakulin, A. V.
Rakhmanov, A. S.
Martin, R. B.
Steele, C. R.
Arnaud, S. B.
Date Acquired
August 21, 2013
Publication Date
December 1, 2001
Publication Information
Publication: Journal of medical primatology
Volume: 30
Issue: 6
ISSN: 0047-2565
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
short duration
Flight Experiment
Cosmos 2229 Project
unmanned
NASA Center ARC
NASA Experiment Number COS 2229-3

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